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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0e867eac527ca2f2ab52ab48c894993d2e9483fee08e9f1c06517b314acfe68f' 
  AND token = 'o2dWtm9c46lPWDddxf0KmyUMcYNIvZGCQhXqEI4Bm40=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}