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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '761e8895fcec964f19d7bd0626710d74da58f1fe7a8e00fd9eebb7b6b271e163' 
  AND token = 'IfTmBSmOQ2JQ78V9mCUfcH+kxI58ywMTOqcKT/axUW8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}