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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2e57646048bfedd177b065b01e8aa3e57cf3f9ca182c0fd84e092819bc2b91f9' 
  AND token = 'EJ0KBEwcF8iNlcXHpFEUIpaOoD8vYQu9Hx0SWpaPqLE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}