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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e80ef2dcee7a48129204e845d481f1a6dbb295e73e9f1d705a210ce6e16bffb0' 
  AND token = 'iJiuTRJhvU15PyGkXSN66yZToXvOpx5SsLEVNjkgXiw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}