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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a52f2f9fe5f1fc4992cce4f51758d3056b4425a877e8ab019482f7d7f9558cc5' 
  AND token = 'R4/m3wNQpdtPXtc+FRqbqTxX8Pc4ubGLzoYfiW4W5J4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}