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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42e816df042ec1bcc0e54a1e95a9ed84d69d5e7b906cf992421eee777e7458a1' 
  AND token = 'vC1sJQtIIlMxD1SLrRAMtV7LP4qmc3zxcgwETa2vs6Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}