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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a4779ff258b16db2fd05030a50b42b53a6254c1d46080b395e9fe1f0541a0115' 
  AND token = 'oKicFmLP+xS092YVBxT4KCU6lJpJwaywmsUd71bKvEg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}