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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '721f986bb6ce4fa27320f8e5290cf6427957e8dbcff20dcf89689cd41c0dc5d6' 
  AND token = 'zG+bK4faHEj7V/g/ye76jQ/eQK08rrdKrCNtVrSrs5Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}