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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '294f8294172e6639f4349b49a9b988290aac68a28a2b1a33b70ed70e131c0ce2' 
  AND token = '3sI8zE04NhcouUnQt0q4R+tQLChXtSk6ptxlJJKzsag=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}