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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '75080295301a4b4f8c393b45b2a9b7a4340ca2db4e22abe7e5c2b379442f5100' 
  AND token = 'go0JGKRmK+BMroCeIOmXHnt5WIGiPXsS/tD0uTnM3Cc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00037

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}