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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '653287725ee29bb8f1348aaf2de8ed40fa8f7583253a59d8b6e5050a89b71612' 
  AND token = '2dmKhLGI1IRAT8oeZiXZcdki8xonAxjC3NETRmMI5aE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}