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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '122a06db789970e2706d2ad347edbf8e144c6cb9fd5cfa021bf561465a7dac5a' 
  AND token = 'lsCVLED9bqA9D+H9/2lHZOznRe32yDmtIK9aC2RQ5Ec=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}