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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f542b8972ba395e870e718c45f3b76bb0017bf5ed5cf8047646c32846dbf225f' 
  AND token = 'fxaUY/QJDK2gtG1xS3Ed/f8M25ECiAYMSJd6/9j/PW0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}