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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '14a7f420eb376fad48a9a97f51b276a9043c2ee71f39626304d9bbd77a313be3' 
  AND token = 'QIPpVx+VL2t8uQGG5vDv+R+qvRptOzSqccbe6KXStVo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}