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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '16d9ba0b9eee7f11ebbac5e86cfc48e4f88654110508593726a2e56b92922a0d' 
  AND token = 'u8k3bWR1NdeZsl0eaNxEryhs9W6fzW3TFiyNKZdvgCg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}