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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1063611f6d325556a186f34825e67a4e4e58e22802f22ce0582264d589f62ef6' 
  AND token = 'DfVMbN+SfgH32a6V4Aa2BgVezLXFrQ8NCyOS/8RCSX0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}