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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a55b2888a1dbfdc4bda56f4eaf618a4dcc520423cc416dbe9f488242f918d3af' 
  AND token = 'ReuTGCDMGu/2iOZj/THrW7m4/02dF5HfeLGqwwTPsq0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}