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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22e103222ffdbd312cecdf0d4bd3add90fcc1e3b96a6f5f7e446c4bea07124a5' 
  AND token = 'pBOS3EnUuGiZTx72iw2IKxdNMSlYkqOpM4CnEsQp4o4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}