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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a22c74f356958c1d5694529882d948d124e1021fea464105c09f4bd49f77d0a5' 
  AND token = 'gyCnwAfyEDCuaoXSdPFHp6t4FKvjAarcrfhuEloM+CQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}