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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22bf2108ac6980a2b78000c43e6519923facd2a1be76bfe12d3784a5677682c0' 
  AND token = 'uMdSa2CdbBYpUBwFvBzNTxDu6GvmiF1JlRJA4WAb6is=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}