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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fe6a63eca416d9f54583d489f34782a0456351e1079ea0e2de8d9696158387e8' 
  AND token = 'nVY50OwZWzX/JnYV2FJPvfEQmxTrk77at81xNBR0Vwc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}