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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '01e78335a400534d5f0359464762dd84d3b9909637063d0889d6acd4392e6b27' 
  AND token = 'b6s6AeFNi+9y4lGH4VccVTss//4PMVZR92XKmykmc+E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}