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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b8bf59df15d22b5de1080d1ef519b208c942bcd29f43f8e3325866d25efd218c' 
  AND token = 'HOUUK22yI5eyLttDJozwigU187plHgqsmyrHmGQV23Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}