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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6166f96c70389b0ee4840eb37f1b5869a6fb94ee35c83befaf68416448750980' 
  AND token = 'ziCxn2qQt3LMCkOPDvM0E+0gG/xd89omNVeUuaPOsAQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}