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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '39927c7fec3751b2595fea18e0e3de9c86376db7b721d1118aee0537d05b3011' 
  AND token = '9PdGc7XeY2z6qhxEBEd1eG27u5EwSTwvkVWdBHxjSgc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}