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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '640d4fd57ede9ae34125a3aa34e3adea3096159e291019ae3e649d4a1f022a0b' 
  AND token = 'nhPH3Wrz/hFNQc6sF2gULjOku6yOYnZ5+m1AwFzkj1w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}