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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed40495cfb99b5211d9041c50978804741eeb6e0165aef67b7c1c776c9fa1fff' 
  AND token = 'l1ct4KzSNF/CZ/qZ/UV2RCT/tDs5z1m4tvjKo3SMN5c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}