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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43ce53da3d4faa0df0fe5e0b19e897d35c0c07f7eb9ae1371d226a180e501134' 
  AND token = 'ld+tpEX9XsatGh+usVU5relBFVVl239mHrWDexi80K0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}