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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c3f1ee93769f6458b51fe7bb6aa4bdeb5a4416ce719ebc155051161ba146a905' 
  AND token = 'Z+sE0NEArx9LIBcuMnMUHRGgIv1lRq/545gjqRHNeso=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}