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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4185957060be303e30972fd09bb34710883101415016571344ea4669baaa3b61' 
  AND token = '1ygAuZU9SHCqjvTMa7160Ro7cXeixReH5e/xn7D4PEk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}