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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c3966cab80ed8691d18ce766a1dcaa305ceea694a773070b7f1067e81ab721a9' 
  AND token = '+4JpQ3eHr37aKDbOHUpvv/CUgLX5ya3xkC5RkPTlEZo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}