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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de4450d11bacf8cef36a7960fb5f7b538eea2b168b405b20031bfec4b2b32f7e' 
  AND token = 'wvl/KU1Jj40pPEMZKJGQo1dQji6RPi6Apwk6myGvEN4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}