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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0c21d38349c31c0b28d74d2d7a05a0eb84998bcb0b2252a596a83270f002a3e8' 
  AND token = 'rhN+jCizoU4Ba9m53Jm1BXTIQlZxYPZG9NX0J2Fxj0s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}