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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53a6fe94a1792ab70e6199dd1f453fe7bd59e7bebfb87413007e042e5e68944a' 
  AND token = 'FHTGXBABopZ2KixbAK4XP73diwalQqY2cAbn+fSFxmQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}