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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7443162e6fcccf49006128b723ff86925f8a7fb08a87c3e1671e0b1164c3e0ce' 
  AND token = 'oDkYSqxrZOaoCCI5t1Cip/Wy/KeX7T86aKNzj6OSnDE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}