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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '66ded35b4337b805766f24341f5c77f5edefad35f7a7bf23f278e9b51105f5e2' 
  AND token = 'lQZYgoH+V0EQtO6IpQwW5LBXMjbkbfxEO9Ve1SURCkg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}