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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fa849eb16c7b0c57b0b227c2a1fe8b45c8a920abc7537975539edde1c8caf744' 
  AND token = 'a05f4gJZOEZiId4aFC/bhs9dT2gHRjSr+njWYspc8eM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}