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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5a8dac80bdfbc072cfce05e6a8030446d6b7e65ee8ec1bb2bcb1d20345e51386' 
  AND token = 'C0GwlNiQl7TU76MVdxmkYpDU6/AfCoG2c2XZcdzz8dQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}