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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e57d48d2af36b80469e0fb4d17b31815cf7c449655134a3550249962fe71b982' 
  AND token = 'A153bHHHhFRZr0CZ2ENEOc/viAByQc+AkFlZpL8C3Qg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}