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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'eb079e674276b7ff03447b388568e87bf2221d6c55485106dd26dba698b0fd7a' 
  AND token = 'JSaINPi1dV4QgPxgTnk9DGFdeD8QHJDr7RE/9DlXFDE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}