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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '19d5e8691869d6c3975f2cfc5924adca3d0bdb47661daec4d12845dd9ec71407' 
  AND token = 'fUZSW6x0wcvzBL0EAapIi4O+TeokzIGOvd6PWJjo1ao=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}