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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8feb849b59ad7b8d8303c32a242073a4d3c887d1d4cdb1b91f4c55aa053186f2' 
  AND token = '2c6z2+khtsMmvb1HwkDdUYbKy+WmYZflHaW2XFpXMiI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}