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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6b478da9042829814a59c84ce86d554572b9325839f916368e1bfefea089b27c' 
  AND token = '2074+tLj26lw5pWL4+jhJIySo04X2NLD2iWmuKw3a88=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}