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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3af7ed7a39f06dd959640f4b9d1dfe127a53281b618025ea72294f27b9096265' 
  AND token = 'OYy1lmg2/irrsw2Eblf7mLWQ/9RLFEAM8O51bX47MMo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}