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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5259815df9a8568bde4f2dc7cc1ba58f02e29f7de5f9c202032a4535904630b0' 
  AND token = 'C4WeAo76mUts2PsxCR8DUhCbkXifbEIzYPSx14Sfk38=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}