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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e00002c347169255c80f327a55b7f172b1a2e855c025fe549c086605432c306c' 
  AND token = 'IUBDnRXkUfhwKfRQr+d8E22UlB1FZU+U9UNItD5aDaQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}