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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ec3fbb43b9f77481ee8625d5e9be53a0e831f00b71518873bf05a4750c3e0045' 
  AND token = 'L9AbyfQUHgx/evpevtkv/EtWTnIgRIeYUthqyRow004=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}