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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3e18ca146af3bf343ab1a2cc54c8f716b621ac8561c485a3f3a5013af375b197' 
  AND token = 'I0897XhWdOyCdm9WLvm6/x193MleZYGOHgf3f1yPXAk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}