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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '397251a8ab9c60d564063411c8cb1a184029bfe0e561c80172b6c5b0c81d0f13' 
  AND token = 'HeYDS2vfK33Gs9xN77H8E8WG+DhgI5SkUhGpMLehGG8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00052

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}