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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b5da3234f54db53a946a3c672e6b42e84b49c0065c0c33c6e5b33bc541899121' 
  AND token = '+jlVTcPnFzuXK/0GnotVtuTETGllagmT0lLWiMbyAxk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}